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韩新亚
2021-03-04 08:45  


       


姓名

韩新亚

性别

最高学位

博士

职称/职务

副教授,硕士生导师,系党支部书记

研究方向

药物化学生物学与生物材料

邮箱

xinyahan@ahut.edu.cn; xinyah@126.com

学习工作经历

2016.6-至今:安徽工业大学,化学与化工学院化学生物学与制药工程系,讲师、副教授

2010.9-2016.6:华中师范大学,化学学院,有机化学专业,理学博士

2006.9-2010.6:青岛农业大学,化学与药学院,制药工程专业,工学学士


主要科研项目及成果

韩新亚,博士,副教授,硕士生导师,化学生物学与制药工程系党支部书记,主要从事药物化学生物学与生物材料研究;先后主持国家重点研发计划专项任务、国家自然科学基金等国家级项目4项、安徽省重点研究与开发计划项目、安徽省自然科学基金面上项目、安徽省高等学校自然科学研究项目(重点)、国家重点实验室开放课题各1项、教育部重点实验室开放课题2项;负责科技部发展中国家杰出青年科学家来华工作计划1项;以第一作者或通讯作者在Org. Lett., J. Chem. Inf. Model, Eur. J. Med. Chem., J. Agric. Food Chem., Sensor Actuat. B-CHEM., J. Mater. Sci. Technol.等国际知名期刊发表高质量论文20余篇。

近期主持的部分科研项目:

1 国家重点研发计划政府间国际科技创新合作重点专项任务,2017YFE0118200,2019.1-2022.12,108万,在研,主持

2 国家自然基金委国际(地区)合作与交流项目任务,32061143045,2021.01-2023.12,50万,在研,主持

3 国家自然科学基金青年项目,82104065,2022.01-2024.12,24万,在研,主持

4 科技部中国--匈牙利科技合作委员会例会交流项目,2018-II-22020.1-2021.1210万,在研,主持

5 科技部中国--乌克兰科技合作委员会例会交流项目CU03-04,2020.1-2021.12,8万,在研,主持

6 安徽省重点研究与开发计划项目201904b11020025,2019.1-2021.12,30万,在研,主持

7 安徽省自然基金面上项目1908085MB35,2019.7-2022.6,10万,在研,主持

8 科技部发展中国家杰出青年科学家来华工作计划,越南-18-0012019.1-2019.1215万,已结题,负责人

9 安徽省高等学校自然科学研究项目(重点项目)KJ2018A0040,2018.1-2019.12,6万,已结题,主持

10 微生物技术国家重点实验室开放课题,M2017-112017.10-2019.910万,已结题,主持

11 农药与化学生物学教育部重点实验室开放课题201801A02,2019.1-2021.129万,在研,主持

12 安徽工业大学校青年基金项目,QZ2016092017.1-2018.120.8万,已结题,主持

13 安徽工业大学人才引进科研启动经费,10万,在研,主持

近期发表的部分论文:

1 Qinghe Gao#, Zhenhua Sun#, Qinfei Xia#, Ruonan Li, Wenlong Wang, Siwei Ma, Yixin Chai, Manman Wu, Wei Hu, Péter Ábrányi-Balogh, György M. Keserű, and Xinya Han*, Vinylation of αAminoazoles with Triethylamine: A General Strategy to Construct Azolo[1,5-a]pyrimidines with a Nonsubstituted Ethylidene Fragment, Org. Lett. 2021, 23, 2664-2669.

2 Qian Chen, Yudie Sun, Shengjun Liu, Jian Zhang, Cheng Zhang, Hui Jiang, Xinya Han*, Lifang He, Suhua Wang, Kui Zhang*, Colorimetric and fluorescent sensors for detection of nerve agents and organophosphorus pesticides, Sensor Actuat. B-CHEM. 2021,344: 130278.

3 Xinya Han, Yunyuan Huang, Lin Wei, Haifeng Chen, Yanrong Guo, Zilong Tang, Wei Hu, Qinfei Xia, Qi Wang, Jufen Yan*, Yanliang Ren*, Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase, Bioorg. Med. Chem. 2020, 28: 115624.

4 Qi Sun#, Yuan Qiu#, Jun Chen, Fengshou Wu, Xiaogang Luo, Yanrong Guo, Xinya Han*, Dawei Wang*, A colorimetric and fluorescence turn-on probe for the detection of palladium in aqueous solution and its application in vitro and in vivo, Spectrochim. Acta Part A 2020, 239, 118547.

5 Ling Jin, Li Zhang, Lei Yang, Xingrong Wua, Cheng Zhang, Kang Wei, Lifang He, Xinya Han*, Hongbin Qiao*, Abdullah M. Asiri, Khalid A. Alamry, and Kui Zhang*, Orange-Red, Green, and Blue Fluorescence Carbon Dots for White Light Emitting Diodes, J. Mater. Sci. Technol. 2020, 50, 184-191.

6 Jun Tang, Yali Cao, Fei Ruan, Fengfeng Li, Yangxin Jin, Minh Ngoc Ha, Xinya Han*, and Qingping Ke*, New Approach for Controllable Synthesis of N-MnOx Micro-flowers and Their Superior Catalytic Performance for Benzoxazole Synthesis, Ind. Eng. Chem. Res. 2020, 59, 9408-9413.

7 Guanqing Yang#, Zhengjie Liu#, Ruilong Zhang*, Xiaohe Tian, Juan Chen, Guangmei Han, Bianhua Liu, Xinya Han, Yao Fu, Zhangjun Hu, and Zhongping Zhang*, A Multi-responsive Fluorescent Probe Reveals Mitochondrial Nucleoprotein Dynamics with Reactive Oxygen Species Regulation through Super-resolution Imaging, Angew. Chem. Int. Ed. 2020, 59, 2-9.

8 Yunyuan Huang#, Lin Wei#, Xinya Han#, Haifeng Chen#, Yanliang Ren*, Yanhong Xu, Rongrong Song, Li Rao, Chen Su, Chao Peng, Lingling Feng, Jian Wan*, Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects, Eur. J. Med. Chem. 2019, 184(15), 111749-11762.

9 Qinghe Gao*,#, Xinya Han#, Peiyuan Tong, Zhiang Zhang, Haotian Shen, YanrongGuo, Suping Bai, Aerobic α,β-C(sp3)-H Bond Difunctionalization and C-N BondCleavage of Triethylamine: Difunctional Ammonium Iodide Enablingthe Regioselective Synthesis of 4-Arylpyrimido[1,2-b]indazoles, Org. Lett. 2019, 21 (15), 6074-6078.

10 Xinya Han#, Xiuyun Zhu#, Zongqin Hong#, Lin We, Yanliang Ren*, Fen Wan, Shuaihua Zhu, Hao Peng, Li Guo, Li Rao, Lingling Feng, and Jian Wan*, Structure-Based Rational Design of Novel Inhibitors Against Fructose-1,6-Bisphosphate Aldolase from Candida albicans, J. Chem. Inf. Model. 2017, 57 (6), 1426-1438.

11 Xinya Han#, Yunyuan Huang#, Rui Zhang#, Shan Xiao, Shuaihua Zhu, Nian Qin, Zongqin Hong, Lin Wei, Jiangtao Feng, Yanliang Ren, Lingling Feng*, and Jian Wan*, New Insight into the Binding Modes of TNP-AMP to the Human Liver Fructose-1,6-bisphosphatase, Spectrochim. Acta Part A 2016, 165 (5), 155-160.

12 Xinya Han#, Xiuyun Zhu#, Shuaihua Zhu#, Lin Wei, Li Rao, Zongqin Hong, Li Guo, Haifeng Chen, Bo Chi, Yan Liu, Lingling Feng, Yanliang Ren*, and Jian Wan*, A Rational Design, Synthesis, Biological Evaluation and Structure−Activity Relationship Study of Novel Inhibitors against Cyanobacterial Fructose-1,6-bisphosphate Aldolase, J. Chem. Inf. Model. 2016, 56 (1), 73-81.

13 Haifeng Chen#, Xinya Han#, Nian Qin#, Lin Wei, Yue Yang, Li Rao, Bo Chi, Lingling Feng, Yanliang Ren,* and Jian Wan* Synthesis and Biological Evaluation of β-Nitrostyrene Derivatives as Antifungal Agents Against Magnaporthegrisea, Bioorg. Med. Chem. 2016, 24 (6), 1225-1230.

14 Ding Li#, Xinya Han#, QidongTu#, Lingling Feng, Di Wu, Yao Sun, Haifeng Chen, Yongjian Li, Yanliang Ren,* and Jian Wan*,Structure-Based Design and Synthesis of Novel Dual-TargetInhibitors Against Cyanobacterial Fructose-1,6-Bisphosphate Aldolase and Fructose-1,6- Bisphosphatase, J. Agric. Food Chem. 2013, 61 (31), 7453-7461.


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