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硕士生导师
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韩新亚
2020-03-04 08:45  

姓名

韩新亚

性别

最高学位

博士

职称/职务

化学生物学与制药工程系讲师,硕士生导师

研究方向

药物分子设计

(定向靶标的新型抑制剂先导结构发现及其调控机制)

邮箱

xinyahan@ahut.edu.cn; xinyah@126.com

学习工作经历

2016.6-至今:安徽工业大学,化学与化工学院,讲师,硕士生导师

2010.9-2016.6:华中师范大学,化学学院,有机化学专业,理学博士

2006.9-2010.6:青岛农业大学,化学与药学院,制药工程专业,工学学士

主要科研项目及成果

近期主持的科研项目:

1中国--匈牙利科技合作委员会例会交流项目,2018-II-22020.1-2021.1210万,主持

2  科技部发展中国家杰出青年科学家来华工作计划,越南-18-0012019.1-2019.1215万,负责人

3山东大学微生物技术国家重点实验室开放课题,M2017-1110万,2017.10-2019.9,主持

4安徽工业大学校青年基金项目,QZ2016090.8万,2017.1-2018.12,主持

5安徽工业大学人才引进科研启动经费,10万,在研,主持

近期发表的主要论文:

1 Zilong Song, Yun Zhu,Jingrui  Liu,ShukeGuo,YuchengGu,Xinya Han*,Hongqiang Dong, Qi Sun,  Weihua Zhang*,Mingzhi Zhang*, Diversity-oriented synthesis and antifungal  activities of novel pimprinine derivative bearing a  1,3,4-oxadiazole-5-thioether moiety, Molecular Diversity 2020, https://doi.org/10.1007/s11030-020-10048-8

2 Yunyuan Huang#,  Lin Wei#, Xinya Han#, Haifeng Chen#,  Yanliang Ren*,Yanhong Xu, Rongrong Song, Li Rao, Chen Su, Chao Peng, Lingling  Feng, Jian Wan*, Discovery of novel allosteric site and covalent inhibitors  of FBPase with potent hypoglycemic effects, European Journal of Medicinal  Chemistry, 2019, 184(15), 111749-11762.

3 Qinghe Gao*,#,Xinya  Han#,Peiyuan Tong, Zhiang Zhang, Haotian Shen, YanrongGuo,  Suping Bai, Aerobic α,β-C(sp3)-H Bond Difunctionalization and C-N  BondCleavage of Triethylamine: Difunctional Ammonium Iodide Enablingthe  Regioselective Synthesis of 4-Arylpyrimido[1,2-b]indazoles, Org. Lett.2019,  21 (15), 6074-6078.

4.Jufen Yan, Jianhua  Zhu*,Mingfang Cui, Jing Zhang, Fang Ma, Yiping Su, and Xinya Han*,Multifunctional  Mineral Hydrogels: Potential in ArtificiallyIntelligent Skins and Drug  Delivery, ACS Omega 2019, 4, 19145-19152.

5Xinya Han#,  Xiuyun Zhu#,Zongqin Hong#, Lin We, Yanliang Ren*, Fen  Wan, Shuaihua Zhu, Hao Peng, Li Guo, Li Rao, Lingling Feng, and Jian Wan*,  Structure-Based Rational Design of Novel Inhibitors Against  Fructose-1,6-Bisphosphate Aldolase from Candida albicans, J. Chem. Inf.  Model. 2017, 57 (6), 1426-1438.

6Xinya Han#,Yunyuan  Huang#,Rui Zhang#, Shan Xiao, Shuaihua Zhu, Nian Qin,  Zongqin Hong, Lin Wei, Jiangtao Feng, Yanliang Ren, Lingling Feng*, and Jian  Wan*, New Insight into the Binding Modes of TNP-AMP to the Human Liver  Fructose-1,6-bisphosphatase, Spectrochim. Acta Part A 2016, 165 (5), 155-160.

7Xinya Han#,Xiuyun  Zhu#,Shuaihua Zhu#, Lin Wei, Li Rao, Zongqin Hong, Li  Guo, Haifeng Chen, Bo Chi, Yan Liu, Lingling Feng, Yanliang Ren*, and Jian  Wan*, A Rational Design, Synthesis, Biological Evaluation and  Structure−Activity Relationship Study of Novel Inhibitors against  Cyanobacterial Fructose-1,6-bisphosphate Aldolase, J. Chem. Inf. Model. 2016,  56 (1), 73-81.

8Haifeng Chen#,Xinya  Han#,Nian Qin#, Lin Wei, Yue Yang, Li Rao, Bo  Chi, Lingling Feng, Yanliang Ren,* and Jian Wan* Synthesis and Biological  Evaluation of β-Nitrostyrene Derivatives as Antifungal Agents Against  Magnaporthegrisea, Bioorg. Med. Chem. 2016, 24 (6), 1225-1230.

9 Ding Li#,Xinya  Han#, QidongTu#, Lingling Feng, Di Wu, Yao Sun,  Haifeng Chen, Yongjian Li, Yanliang Ren,* and Jian Wan*,Structure-Based  Design and Synthesis of Novel Dual-TargetInhibitors Against Cyanobacterial  Fructose-1,6-Bisphosphate Aldolase and Fructose-1,6- Bisphosphatase, J.  Agric. Food Chem. 2013, 61 (31), 7453-7461.

学术会议报告:

1、基于C.  albicans果糖-1,6-二磷酸醛缩酶结构的新型抑制剂合理设计,第十届全国化学生物学学术会议口头报告,中国武汉,20179.23-9.26

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